The Test of DLCO Is A Valuable Predictor for Prognostic Determination of Patients with Chronic Obstructive Pulmonary Disease

Dina Okfina Ria, Suradi Suradi, Jatu Aphridasari, Reviono Reviono, Dono Indarto

Abstract


Background: Chronic obstructive pulmonary disease (COPD) is characterized by permanent and progressive air way obstruction. In terms of morbidity, this disease is the first highest pulmonary disease in the world. DLCO is used for measurement of gas transfer from alveoli to blood capillary and Hb level is one of the main factors affecting the gas transfer. The aim of this study was to examine prognosis of patients with stable COPD using lung function, DLCO and Hb tets.
Methods: Consecutive sampling was used to recruit 33 outward patients who suffered stable COPD and visited the Lung Clinic at Public Hospital dr. Moewardi Surakarta. Classification of COPD was determined using GOLD 2016. Airway and lung functions were examined using spirometry and single breath DLCO. Hb level was measured using cyamethemoglobin method. All collected data were analyzed using student t test and p value was set up P<0.05.
Results: DLCO value in group A and group C was 100.24±31.15% and 75.42±20.67%, higher than that of DLCO value in group D 46,5017,50% and it reached significantly difference (P<0,001 and P=0,010 respectively). Higher Hb level was observed in group A (15±0.72 g/dL), followed by group D (14.23±1.50 g/dL), group C (14.12±1.26 g/dL) and group B (13.37±2.54 g/dL). However, it was not statistical difference (P=0,118).
Conclusion: More severe COPD status has lower value of DLCO. Patients with stable COPD in group A have a better prognosis compared with group B, C and D. (J Respir Indo 2018; 38(2): 83-92)

Keywords


COPD, DLCO, Hb level, spirometry

Full Text:

PDF

References


Global Initiative for Chronic Obstructive Lung (GOLD), Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease update 2016. [Cited 2016 April 8th]. Available from: http://www.goldcopd.org/uploads/users/files/GOLD_Report_2016_Jan6.pdf

DepKes RI, 2008. Pedoman pengendalian penyakit paru obstruktif kronik. Keputusan Menteri Kesehatan Republik Indonesia Nomor 1022/Menkes/SK/XI/2008. Jakarta: Depkes; [updated 2008; cited 2012 January 12th]; Available from: http://www.pppl.depkes.go.id/imagesdata.

Barnes PJ. The cytokine network in asthma and chronic obstructive pulmonary disease. The Journal of Clinical Investigation. 2008;18:3546-56.

Suradi. Pengaruh rokok pada penderita penyakit obstruktif kronik (PPOK): tinjauan pathogenesis, klinis dan sosial. [Pidato Pengukuhan Guru Besar Pulmonologi dan Ilmu Kedokteran Respirasi Falkutas Kedokteran Universitas Sebelas Maret]. Surakarta: Universitas Sebelas Maret; 2007. p.1-17

Fishman AP. Milestones in the history of pulmonary medicine. In: Fishman AP, Elias JA, Fishman JA, Grippi MA, Senior RM, Pack Al, editors. Fishman´s pulmonary diseases and disorder. 4th ed. New York: MCGraw-Hill; 2008. p.4-18.

Jardin TD. The diffusion of pulmonary gases. In Esperti CL, editor. Cardiopulmonary anatomy and physiology : essentials for respiratory care. 4thed. Columbia : Delmar Thompson Leraning; 2002. p.117-41.

West JB. Diffusion. In: West JB, editor. Respiratory physiology: The essential. 9th ed. Philadelphia: Lippincot william and wilkins; 2012. p.25-51.

Wanger J CJ, Coates A, Pedersen OF, Brusasco F, et al. Standardisation of the measurement of lung volumes. European Respiratory Journal. 2005:511-22.

Yohannes MA, and Ershler BW. Anemia in COPD:A systematic Review of the Irevalence, Quality of life, and Mortality. Respiratory Care. 2011;56:644-52.

Jian G, Zhang C, Xio C, et al. Impac of anemia on lung function and exercise capacity in patients with stable severe chronic obstructive pulmonary disease. British Medical Journal Open. 2015;5:1-6.

Brashier BB, and Kodgule R. 2012. Risk Factors and Pathophysiology of Chronic Obstructive Pulmonary Disease (COPD). Supplement to Journal of Association Physiccian India. 2012;60:17-21.

Khoirudin. Perbedaan kapasitas vital paru dan tekanan darah antara perokok aktif dengan perokok pasif pada siswa madrasah hidayatul mubtadi di Semarang. Semarang: Universitas Negeri Semarang; 2006. p.32-7.

Carroz PK and Morera J. Anemia in chronic obstructive pulmonary disease. Department of Pneumology Hospital Germans Trias I Pujol. 2012. [cited 2016 September 16th]. Available from:http://www.intechopen.com/books/anemia/anemia-in-chronic-obstructive-pulmonary-disease.

Sin BA, Akkoca O, Saryal S, Oner F, Misirligil Z,. Differences between asthma and COPD in the elderly. Journal of investigational allergology & clinical immunology. 2006;16:44-50.

Fujimoto K, Kitaguchi Y, Kubo K, Honda T. Clinical analysis of chronic obstructive pulmonary disease phenotypes classified using high-resolution computed tomography. Respirology. 2006;11:731-40.

Deesomchok A, WebbKA, Lam YM, Ofir D, Jensen D, O'Donnel DE. Lung hyperinflation and its reversibility in patien with airway obstruction of varying severity. Journal of Chronic Obstructive Pulmonary Disease. 2010;7:428-37.

Agusti A, Edward LD, Celli B, Macnee W, Caverly PM, Mullerova H, et al. Characteristic stability and outcomes of the 2011 GOLD COPD grups in the ECLIPSE cohort. European Respiratory Journal. 2013;42:636-46.

Saraydin M, Altintas N, Ince O. relationships between lung functions and extend of emphysema in patients with COPD. Journal of Pulmonary and Respiratory Medicine. 2014;4:1-5.

Guyton AC, and Hall JE. Physical priciples of gas exchange; diffusion of oxygen and carbon dioxide through the respiratory membrane. In: Guyton AC, editor. Textbook of medical physiology. 11th ed. Philadelpia: Elsevier Saunders; 2011. p.491-501.

Zogg S, Durr S, Miedinger D, Steveling EH, Maier S, Leuppi JD. Differences in classification of COPD patiens into risk groups A-D: a cross-sectional study. BMC Research Notes. 2014;7:1-8.

Ismail E, Yunus F, Damayanti T. Hubungan antara hasil pemeriksaan kapasitas difusi paru terhadap karbon monoksida (DLCO) metode napas tunggal derajat obstruksi penderita PPOK di RSUP Persahabatan Jakarta. Departemen Pulmonologi dan Ilmu kedokteran Respirasi FKUI; 2015. p.1- 54.

Kim V and Criner JG. Chronic bronchitis and chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 2013;187;228-37.

Vasquez A, and Logomarso JV. Anemia in Chronic obstructive pulmonary disease and the potensial role of iron deficiency. Journal of Chronic Obstructive Pulmonary Disease. 2016;13:100-9.

Boutou AK, Shrikhrisna D, Tanner RJ, Smith C, Kelly JL, Ward SP, et al. Lung function indieces for predicting mortility in COPD. European Respiratory Journal. 2013;42:616-25.

Sakar M, Rajta MP, and Khatara J. Anemia in chronic obstructive pulmonary disease: Prevalnsi pathogenesis and potensial impac. Lung India. 2015;32:142-51.

Enright PL, Stoller JK, Hollingsworth H. Diffusing capacity for carbon monoxide (DLCO); [update 2014; cited 2015 Oktober 6th]; Available from: http://www.uptodate.com/contents/diffusing-capacity-for-carbon-monoxide.

Maclntyre N, Crapo RO, Viegi G, Jhonson DC, Van der Gritten CPM, Brusasco V. Standardisation of the single-breath determination carbon monoxide uptake in the lung. European Respiratory Journal. 2005;26:720-35.




DOI: https://doi.org/10.36497/jri.v38i2.162

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 Jurnal Respirologi Indonesia


INDEXING & PARTNER

SINTA Garuda Indonesian Scientific Journal Database (ISJD) Indonesia One Search (IOS) Crossref

ROAD-ISSN Dimensions Google Scholar 

 

Jurnal Respirologi Indonesia
pISSN: 0853-7704 - eISSN: 2620-3162
Address: Jalan Cipinang Bunder No. 19, Cipinang, Pulogadung, Jakarta Timur, DKI Jakarta 13240, Indonesia
Phone: +62-21-2247-4845
Email: editor@jurnalrespirologi.org


An official publication by
the Indonesian Society of Respirology (ISR)

Creative Commons License
Creative Commons Attribution-ShareAlike 4.0 International License

Statcounter