The Effect of Thymoquinone on Interleukin-8 Levels, %FEV1 and CAT Scores in Chronic Obstructive Pulmonary Disease
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Global Initiative For Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. USA: GOLD Science Committee University of Wisconsin; 2019. p. 4-95.
Kementerian Kesehatan Republik Indonesia Penyajian Pokok-Pokok Hasil Riset Kesehatan Dasar 2013. Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI. Jakarta: Litbang; 2013: 1-69.
Macnee W. ABC of chronic obstructive pulmonary disease pathology, pathogenesis, and pathophysiology. BMJ. 2006;332:1202-4.
Suradi. Analisa gas darah. In: Rasmin M, Jusuf A, Amin M, Nawas MA, Rai IBN, Yunus F, et al, editors. Buku Ajar Pulmonologi dan Kedokteran Respirasi. 1st ed. Jakarta: UI Press; 2017. p. 285-300.
Perhimpunan Dokter Paru Indonesia. Penyakit paru obstruktif kronik diagnosis dan penatalaksanaan. Jakarta: UI Press; 2016. p. 1-88.
Woo CC, Kumar AP, Sethi G, Tan KH. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol. 2012;83:443-51.
El Gazzar MA, Mezayen RE, Nicolls MR, Dreskin SC. Thymoquinone attenuates proinflammatory responses in lipopolysaccharide-activated mast cells by modulating NF-ꝃβ nuclear transactivation. Biochimica et Biophysica Acta. 2007;1770:556-64.
Sholihah M, Suradi, Aphridasari J. Pengaruh Pemberian Quercetin Terhadap Kadar Interleukin 8 (IL-8) Dan Nilai COPD Assessment Test (CAT) Pasien Penyakit Paru Obstruktif Kronik (PPOK) Stabil. J Respir Indo 2019 april;39(2):103-12.
Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016;138:16-27.
Siveen KS, Mustafa N, Li F, Kannaiyan R, Ahn KS, Kumar AP, et al. Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NFκB regulated gene products in multiple myeloma xenograft mouse model. Oncotarget. 2013;5:634-48.
Baker RG, Hayden MS, Ghosh S. NF-κβ, inflammation, and metabolic disease. Cell Metab. 2011;13:1-24.
Wafaa S, Shirny El, Ayman S, Dib El, Nagy, Hala M, et al. A study of IL-6, IL-8, and TNF-α as inflammatory markers in COPD patients. Egypt J Bronchol. 2014;8:91-9.
Anwar A, Massi MN, Patellongi IJ, Dewiyanti W. Levels of the proinflammatory cytokines: interleukin-8, interleukin-12, tumor necrosis factor-α in severe acne at Makassar. Int J Biol Med Res. 2015;6(1):4718-21.
Wihandani DM, Dewi NA, Somia A. Sekresi interleukin-8 (il-8) dan hubungannya dengan tingkat keparahan penyakit infeksi dengue. J Peny Dalam. 2009;10:1-5.
Zhang J, Bai C. The significance of serum interleukin-8 in acute exacerbations of chronic obstructive pulmonary disease. Tanaffos. 2018;17(1):13-21.
Umar S, Zargan J, Umar K, Ahmad S, Katiyar CK, Khan HA. Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. Chem Biol Interact. 2012;197:40-6.
Balaha MF, Tanaka H, Yamashita H, Rahman MN, Inagaki N. Oral Nigella sativa oil ameliorates ovalbumin-induced bronchial asthma in mice. Int Immunopharmacol. 2012;14:224-31.
Hadi V, Kheirouri S, Alizadeh M, Khabbazi A, Hosseini H. Effect of nigella sativa oil extract on inflammatory cytokine response andoxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. AJP. 2016;6:34-43.
Yetkin NA, Buyukoglan H, Sonmez MF, Tutar N, Yilmaz I, Gulmez I. The protective effects of thymoquinone on lung damage developed by cigarette smoke. Eur Respir J. 2017;50:1-8.
Bhatt SP, Balte PP, Schwartz JE, Cassano PA, Couper D, Jacobs DR, et al. Discriminative accuracy of FEV1: FVC thresholds for copd-related hospitalization and mortality. JAMA. 2019;321:2438-47.
Lareau RN, Bonnie RN, Paula M. Chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med. 2013;171:1-2.
Ahmad J, Khan RA, Malik MA. A study of Nigella sativa oil in the management of wheeze associated lower respiratory tract illness in children. Afr J Pharm Pharmacol. 2009;3(5):248-51.
Boskabady MH, Javan H, Sajady M, Rakhshandeh H. The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients. Fun Clin Pharmacol. 2007;21:559-66.
Koshak A, Wei L, Koshak E, Wali S, Alamoudi O, Demerdash A, et al. Nigella sativa supplementation improves asthma control and biomarkers: A randomized, double‐blind, placebo‐controlled trial. Phytother Res. 2017;31:403-9.
Salem AM, Bamosa AO, Qutub HO, Gupta RK, Badar A, Elnour A, et al. Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial. Ann Saudi Med. 2017;37:64-71.
DOI: https://doi.org/10.36497/jri.v40i4.145
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