Effect Of Nigella sativa Cement Extract on Procalcitonin, TNF-α Level and Time to Clinical Stable in Pneumonia Patients

Lusiana Susilo Utami, Reviono Reviono, Suradi Suradi, Harsini Harsini, Jatu Aphridasari


Background: Pneumonia is an infectious disease with highest morbidity and mortality in the world. The research objectives is to determine the effect of Nigella sativa cement extract in procalcitonin, TNF-α levels, and clinical improvement in pneumonia patients.
Methods: This study is a clinical trial quasi experimental design with pre and post test approach in the treatment group and the comparison group. Samples were taken by consecutive sampling between April and May 2016 a total of 30 patients were divided into 2 groups:the treatment group and the comparison group. The treatment group was given additional therapy capsules Nigella sativa cement extract, the comparison group was given the standard therapy. Procalcitonin levels and TNF-α is checked when the patient was admitted and when clinical improvement is achieved.
Results: Decreased levels of procalcitonin in the treatment group (8.969±13.591 ng/dl) and a comparison group (1.907±6293 ng/dl) was statistically significant (p= 0.014; 95 % CI= 0.222-1.770). Decreased levels of TNF-α was not significantly different between treatment groups (58.759(1.840-166.50) pg/dl) and a comparison group (57.485 (35.410-81.650) pg/dl), with p= 0.395. The achievement of clinical improvement in the treatment group 4.60±8.28 days and the comparison group 5.53 ±1.45 today, statistically no difference between the two groups.
Conclusion: Capsule Nigella sativa cement extract provides benefit for declining levels of procalcitonin and accelerate achievement of clinically stable in pneumonia patients. (J Respir Indo. 2017; 37(4): 316-24)


Pneumonia, Nigella sativa, procalcitonin, TNF-α

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Akter S, Shamsuzzaman SM, Jahan F. Community acquired bacterial pneumonia: aetiology, laboratory detection, and antibiotic susceptibility. Malaysian J Pathol. 2014;36:97-103.

Perhimpunan dokter paru Indonesia. Pneumonia komunitas: Pedoman diagnosis dan penatalaksanaan di Indonesia. Jakarta: PDPI; 2014. p.1-52.

Meijvis SCA, Garde EMV, Rijkers GT, Bos WJW. Treatment with anti-inflammatory drugs in community acquired pneumonia. Journal of Internal Medicine. 2012;272:25-35.

Bacci MR, Leme RCP, Zing NPC, Murad N, Adami F, Hinnig PF, et al. IL-6 and TNF-a serum levels are associated with early death in community-acquired pneumonia patients. Brazilian Journal of Medical and Biological Research. 2015;48(5):427-32.

Gilbert DN. Procalsitonin as a biomarker in respiratory tract infection. Clin Infect Dis. 2011;52:346-50.

Albrich W, Schuetz W, Mueller B. Procalsitonin for diagnosis of infection and guide to antibiotic decicions:past, present, and future. BMC med. 2011;9:107-16.

Parnham MJ. Immunomodulatory approaches to the treatment of infections. Croatian Journal of Infection. 2011:31(1):15–27.

Halawani E. Antibacterial activity of thymoquinone and thymohydroquinone of Nigella sativa and their interaction with some antibiotics. Advances in Biological Research. 2009;3:148-52.

Al kharfi KM, Ahmad A, Raish M, Vanhoutte PM. Thymoquinone modulates nitric oxide production and improves organ dysfunction of sepsis. Life Sciences. 2015;143:131–8.

Singh A, Ahmad I, Akhter S, Ahmad MZ, Khan ZI, Ahmad FJ. Thymoquinone: major molecular targets, prominent pharmacological actions and drug delivery concerns. Current Bioactive Compound. 2012;8:1-12.

Alenzi FQ, Altamimi MA, Tarakji B, Tamimi W, Bagader O, Al-shangiti A et al. Antioxidant properties of Nigella sativa. Mol Genet Med. 2013;7:3-8.

Dewantara A, Reviono, Suradi. Pengaruh pemberian zink selama 5 hari terhadap kadar endothelin-1, tumor necrosis faktor-α dan perbaikan klinis penderita pneumonia. [Thesis] Surakarta: Universitas Sebelas Maret. 2015.

Rothberg MB, Haessler S, Lagu T, Lindenaeur PK, Pekow PS, priya A. Outcomes of patients with healthcare-associated pneumonia: worse disease or sicker patients? Infect. Control Hosp. Epidemiol. 2014;35:3-13.

Phung DT, Wang Z, Rutherford S, Huang C, Chu C. Body mass index and risk of pneumonia: a systematic review and metaanalysis. Obes rev. 2013;14(10):839-57.

Torres A, Peetermans WE, Viegi G, Blasi F. Risk factors for community-acquired pneumonia in adults in Europe: a literature review. Thorax. 2013;68:1057-65.

Chaudhary A, Sumant GI, Jayaprada R, Kalawat U, Ramana BV. Procalsitonin in sepsis and bacterial infections. J Clin Sci Res. 2013;2:216-24.

Ali B, Amin S, Ahmad J, Ali A, Ali M, Showkat R. Bioavailability enhancement studies of amoxicillin with Nigella. Indian J Med Res. 2012;35:555-9.

Mukhopadhyay S, Hoidal J, Mukherjee TK. Role of TNF-α in pulmonary pathophysiology. Respiratory Research. 2006;7:125-34.

Dirjomulyono M, Kristiyono I, Tjandrawinata RR, Noviarny D. Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. Int. Journal of Clinical Pharmacology and Therapeutics. 2008;46(6):295-306.

Takada K, Matsumoto S, Kojima E, Iwata S, Ninomiya K, Tanaka K, et al. Predictors and impact of time to clinical stability in community-acquired pneumococcal pneumonia. Respiratory Med. 2014;108(5):806-12.

DOI: https://doi.org/10.36497/jri.v37i4.87


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