Correlation between Measurement of Lung Diffusion Capacity Using Single Breath Methods (DLCO-SB) and COPD Group in Persahabatan Hospital Jakarta

Authors

  • Efriadi Ismail Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia
  • Faisal Yunus Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia
  • Triya Damayanti Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia

DOI:

https://doi.org/10.36497/jri.v41i4.218

Keywords:

spirometry, diffusing capacity of the lung for carbon monoxide (DLCO), COPD, comorbidities

Abstract

Background: This was a preliminary study to measure DLCO-SB on COPD patients in Persahabatan Hospital to understand the prevalence of DLCO reduction among COPD patients.

Methods: This was a cross sectional study of COPD patients who attended COPD-Asthma clinic in Persahabatan Hospital Jakarta. Spirometry and DLCO-SB were performed consecutively during May–July 2015.  Comorbidities were also recorded.

Results: Spirometry and DLCO-SB measurements were conducted on 65 COPD subjects of which 10.8% subjects were in COPD Group A, 29.2% Group B, 32.3% Group C and 27.7% Group D. The mean age was 64.15; mean FEV1% was 46.05%, mean DLCO measured was 19.42 ml/min/mmHg and the mean DLCO% was 72.00%. The proportion of DLCO decline among COPD patients was 56.92%.  There were significant correlations between COPD group, GOLD COPD grade, FEV1, BMI and comorbidities with the DLCO value results. There were no significant correlation between DLCO value with sex, age, smoking history, Brinkmann Index, obstructive-restrictive criteria, comorbidities and length of COPD period.

Conclusion: The proportion of DLCO decline among COPD patients was 56.92%. There were significant correlations between COPD group, GOLD COPD grade, FEV1, BMI and previous TB history with the results of DLCO.

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References

Global Initiative for Chronic Obstructive Lung (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Global Initiative for Chronic Obstructive Lung (GOLD); 2015.

Tim Kelompok Kerja Penyakit Paru Obstruktif kronik (PPOK). Pedoman praktis diagnosis dan penatalaksanaan Penyakit Paru Obstruktif kronik (PPOK) di Indonesia. Perhimpunan Dokter Paru Indonesia (PDPI). 2011;

Casanova C, de Torres JP, Aguirre-Jaíme A, Pinto-Plata V, Marin JM, Cordoba E, et al. The progression of chronic obstructive pulmonary disease is heterogeneous: the experience of the BODE cohort. Am J Respir Crit Care Med. 2011;184(9):1015–21.

Celli BR. Update on the management of COPD. Chest. 2008;133(6):1451–62.

Morrison NJ, Abboud RT, Ramadan F, Miller RR, Gibson NN, Evans KG, et al. Comparison of single breath carbon monoxide diffusing capacity and pressure-volume curves in detecting emphysema. Am Rev Respir Dis. 1989;139(5):1179–87.

Stephen Spiro, Gerard Silvestri AA. Clinical Respiratory Medicine 4th Edition. Philadelpia: Elsevier saunders; 2012. 37–49 p.

Mason RJ, Broaddus VC, Martin TR, King TE, Schraufnagel D, Murray JF, et al. Ventilation, blood flow, and gas exchange. In: Murray and Nadel’s Textbook of Respiratory medicine. Philadelphia: Elsevier saunders; 2010. p. 53–88.

West JB. Respiratory system understress. In: Respiratory Physiology: the essentials. 9th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & WilkinsWolters Kluwer Health/Lippincott Williams & Wilkins; 2012. p. 141–58.

Deesomchok A, Webb KA, Forkert L, Lam Y-M, Ofir D, Jensen D, et al. Lung hyperinflation and its reversibility in patients with airway obstruction of varying severity. COPD. 2010;7(6):428–37.

Sin BA, Akkoca O, Saryal S, Oner F, Misirligil Z. Differences between asthma and COPD in the elderly. J Investig Allergol Clin Immunol. 2006;16(1):44–50.

Miravitlles M, Soler-Cataluña JJ, Calle M, Molina J, Almagro P, Quintano JA, et al. A new approach to grading and treating COPD based on clinical phenotypes: summary of the Spanish COPD guidelines (GesEPOC). Prim Care Respir J. 2013;22(1):117–21.

Boutou AK, Shrikrishna D, Tanner RJ, Smith C, Kelly JL, Ward SP, et al. Lung function indices for predicting mortality in COPD. Eur Respir J [Internet]. 2013;42(3):616 LP – 625. Available from: http://erj.ersjournals.com/content/42/3/616.abstract

Zhang W, Lu H, Peng L, Ren X, Lu Y, An L, et al. Chronic bronchitis leads to accelerated hyperinflation in COPD patients during exercise. Respirology. 2015;20(4):618–25.

Chugh T, Goel N, Bhargava SK, Kumar R. Correlation of Physiological and Radiological Characteristics in Chronic Obstructive Pulmonary Disease. Indian J Chest Dis Allied Sci. 2012;54:235.

Hanif MA. Skor gabungan curb 65 dan rasio kapasitas inspirasi kapasitas paru total sebagai prediktor mortalitas dan eksaserbasi pada ppok dalam satu tahun. Universitas Indonesia; 2013.

Hastuti W. The role of modification of CURB-65 score as prediction factor for one year mortality in acute exacerbation of chronic obstructive pulmonary disease. Universitas Indonesia; 2013.

Miniati M, Monti S, Pavlickova I, Bottai M. Survival in COPD: impact of lung dysfunction and comorbidities. Medicine (Baltimore). 2014;93(12):e76.

Andrianopoulos V, Franssen FME, Peeters JPI, Ubachs TJA, Bukari H, Groenen M, et al. Exercise-induced oxygen desaturation in COPD patients without resting hypoxemia. Respir Physiol Neurobiol. 2014;190:40–6.

Casanova C, Marin JM, Martinez-Gonzalez C, de Lucas-Ramos P, Mir-Viladrich I, Cosio B, et al. Differential Effect of Modified Medical Research Council Dyspnea, COPD Assessment Test, and Clinical COPD Questionnaire for Symptoms Evaluation Within the New GOLD Staging and Mortality in COPD. Chest. 2015;148(1):159–68.

González-García M, Maldonado Gomez D, Torres-Duque CA, Barrero M, Jaramillo Villegas C, Pérez JM, et al. Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease. J Bras Pneumol publicacao Of da Soc Bras Pneumol e Tisilogia. 2013;39(2):147–54.

Fujimoto K, Kitaguchi Y, Kubo K, Honda T. Clinical analysis of chronic obstructive pulmonary disease phenotypes classified using high-resolution computed tomography. Respirology. 2006;11(6):731–40.

Sariaydin M, Altintas N, Ince O. Relationship between Lung Functions and Extent of Emphysema in Patients with Chronic Obstructive Pulmonary Disease. Eurasian J Pulmonol. 2015;16(3):159–63.

Tanabe N, Muro S, Hirai T, Oguma T, Terada K, Marumo S, et al. Impact of exacerbations on emphysema progression in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011;183(12):1653–9.

Lee JS, Ra SW, Chae EJ, Seo JB, Lim SY, Kim T-H, et al. Validation of the lower limit of normal diffusing capacity for detecting emphysema. Respiration. 2011;81(4):287–93.

Brusasco V, Barisione G, Crimi E. Pulmonary physiology: future directions for lung function testing in COPD. Respirology. 2015;20(2):209–18.

McCormack MC, Stoller JK, Hollingsworth H. Diffusing capacity for carbon monoxide [Internet]. UpToDate. 2012 [cited 2012 Oct 8]. Available from: https://www.uptodate.com/contents/diffusing-capacity-for-carbon-monoxide

Mohammed NH. Lung Diffusing Capacity for Carbon Monoxide (DLco-SB): the Influence of Cigarette Smoking. Iraqi Postgrad Med J. 2010;9(3):328–34.

Han MK, Agusti A, Calverley PM, Celli BR, Criner G, Curtis JL, et al. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med. 2010;182(5):598–604.

Allwood BW, Gillespie R, Galperin-Aizenberg M, Bateman M, Olckers H, Taborda-Barata L, et al. Mechanism Of Airflow Obstruction In Tuberculosis-Associated Obstructive Pulmonary Disease (TOPD). In: D39 CONNECTING THE DOTS: DRAWING LINES BETWEEN COPD AND COMORBID CONDITIONS [Internet]. American Thoracic Society; 2014. p. A5832–A5832. (American Thoracic Society International Conference Abstracts). Available from: https://doi.org/10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A5832

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Published

2021-11-27

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Original Article

How to Cite

Correlation between Measurement of Lung Diffusion Capacity Using Single Breath Methods (DLCO-SB) and COPD Group in Persahabatan Hospital Jakarta. (2021). Jurnal Respirologi Indonesia, 41(4), 260-271. https://doi.org/10.36497/jri.v41i4.218

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