Analysis of Clinical Manifestation at Admission and Comorbidity on Clinical Outcome of COVID-19 Patients in RSUDZA Banda Aceh

Heliyana Isma, Yunita Arliny, Dewi Behtri Yanifitri, Budiyanti Budiyanti, Teuku Zulfikar


Background: Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV- 2 virus and has become a pandemic until now. Clinical outcomes in patients vary depending on many factors, such as demographics, vital signs, laboratory results, and comorbidities.

Methods: This study aims to analyze clinical outcomes in COVID-19 patients associated with the patient's general information (age, sex), demographic factors, admission vital signs, degree of symptoms at admission, blood laboratory results at admission, and comorbidities. This study is an analytic observational study with a cross-sectional design. All variables were examined based on medical records at the time of admission to the hospital. A multivariate analysis was conducted to determine what factors most influence clinical outcomes in treated COVID-19 patients.

Results: There were 183 COVID-19 patients included in this study with moderate to critical degrees. Factors that influence the clinical outcome of COVID-19 patients are the presence of comorbidities, old age, high blood pressure and heart rate, anemia, leukocytosis, and increased blood sugar and creatinine at admission. Multivariate analysis showed that clinical symptoms of severe COVID-19 were a factor that influenced poor clinical outcomes in COVID-19 patients, with OR=5.6 (95% CI=2.223-13.90).

Conclusion: Age, comorbidity, blood pressure, heart rate, hemoglobin, random blood glucose, and creatinine at admission influence the clinical outcome of admitted COVID-19 patients.


COVID-19, clinical outcome, demographic, vital signs, degree of symptoms, laboratorium result, comorbidity

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World Health Organization. Weekly Operational Update on COVID-19. 2020.

Guan W, Liang W, Zhao Y, Liang H, Chen Z, Li Y. Comorbidity and Its Impact on 1590 Patients with COVID-19 in China : A Nationwide Analysis. Eur Respir J 2020;55:1–14.

Sanyaolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P. Comorbidity and its Impact on Patients with COVID-19. SN Compr Clin Med 2020;

Karyono D, Wicaksana A. Current Prevalence, Characteristics, and Comorbidities of Patients with COVID-19 in Indonesia. J Community Empower Heal [Internet] 2020;3(2):77. Available from:

Biswas M, Rahaman S, Biswas T, Haque Z, Ibrahim B. Association of Sex, Age, and Comorbidities with Mortality in COVID-19

Patients: A Systematic Review and Meta- Analysis. Intervirology [Internet] 2021;64(1):36–47. Available from:

Zhang J, Dong X, Cao Y, Yuan Y. Clinical Characteristics of 140 Patients Infected with SARS-CoV-2 in Wuhan, China. Allergy [Internet] 2020;75(7):1730–1741. Available from:

Chatterjee N, Jensen P, Harris A, Nguyen D, Huang H, Cheng R. Admission Respiratory Status Predicts Mortality in COVID-19. Influ Other Respi Viruses [Internet] 2021;15(5):569–572. Available from:

Tharakan S, Nomoto K, Miyashita S, Ishikawa K. Body Temperature Correlates with Mortality in COVID-19 Patients. Crit Care [Internet] 2020;24(1):298. Available from:

Mejía F, Medina C, Cornejo E, Morello E, Vásquez S, Alave J. Oxygen Saturation as a Predictor of Mortality in Hospitalized Adult Patients with COVID-19 in a Public Hospital in Lima, Peru. PLoS One [Internet] 2020;15(12):1–11. Available from:

Chidambaram V, Tun N, Haque W, Majella M, Sivakumar R, Kumar A. Factors Associated with Disease Severity and Mortality Among Patients with COVID-19: A Systematic Review and Meta-analysis. PLoS One [Internet] 2020;15(11):1–10. Available from:

Wang W, Shen M, Tao Y, Fairley C, Zhong Q, Li Z. Elevated Glucose Level Leads to Rapid COVID-19 Progression and High Fatality. BMC Pulm Med [Internet] 2021;21(1):64. Available from: cles/

Lim S, Bae J, Kwon H-S, Nauck M. COVID-19 and Diabetes Mellitus: from Pathophysiology to Clinical Management. Nat Rev Endocrinol 2020;1–20.

Yusnanda. Data Diabetes Melitus di Kota Banda Aceh: Dinas Kesehatan Kota Banda Aceh [Internet]. Dinas Kesehat. Banda Aceh2018 [cited 2021 Oct 20];1–10. Available from: BAB I.pdf?sequence=9&isAllowed=y

Nishiga M, Wang D, Han Y, Lewis D, Wu J. COVID-19 and Cardiovascular Disease: from Basic Mechanisms to Clinical Perspectives. Nat Rev Cardiol 2020;1–16.



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Jurnal Respirologi Indonesia
pISSN: 0853-7704 - eISSN: 2620-3162
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