Analysis of Demographic Factor, Vital Sign, Degree of Symptom, Laboratorium Result and Comorbidity To Clinical Outcome of COVID-19 Patients In RSUDZA Banda Aceh
Abstract
Background: Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2 which leads to respiratory to systemic symptoms, it became pandemic until current. Clinical outcome of patients are varied depend to several factors. Methods: This study aimed to analyze clinical outcome, whether good or bad outcome of COVID-19 patients which related to demographic factors, vital signs, degree of symptom, laboratorium result and comorbidity. This study was an observational analytic study with cross sectional design. The samples were collected by total sampling method. All variables were analyzed toward medical record while admission. Bivariable and multivariable analysis were done to identify which factor who were most influence the clinical outcome of inhospital COVID-19 patients.
Results: Of 183 COVID-19 patients who were admitted, there were 80 patients (43,72%) with moderate degree, 77 patients
(42,08%) with severe degree and 26 patients (14,21%) were critically ill.There were 80 patients (43,72%) who had no
comorbidity and the rest were hypertension and cardiovascular disease in 39 patients (21,31%), diabetes melitus in 37 patients (20,22%), CKD in 13 patients (7,10%), COPD in 3 patients (1,64%), and other diseases in 11 patients (6,01%). There were significantly corelation among comorbidity and clinical outcome (p<0,001). Of demographic factors, age has been corelated to clinical outcome (p<0,001). Of vital sign variable, only blood pressure and heart rate who were corelated to clinical outcome (p=0,020 and p<0,001, respectively). Of laboratorium result, hemoglobin, leucocyte, random blood glucose and creatinine were corelated to clinical outcome (p=0,030, p=0,001, p<0,001, p<0,001 respectively). Multivariable analysis were done to show that severe degree of COVID-19 were most influenced toward clinical outcome with OR 5,6 (95%CI 2,223-13,90).
Conclusion: Age, comorbidity, blood pressure, heart rate, hemoglobin, random blood glucose and creatinin at admission are factors that influence clinical outcome of admitted COVID-19 patients.Keywords
Full Text:
PDFReferences
World Health Organization. Weekly Operational Update on COVID-19. 2020.
Guan W, Liang W, Zhao Y, Liang H, Chen Z, Li Y. Comorbidity and Its Impact on 1590 Patients with COVID-19 in China : A Nationwide Analysis. Eur Respir J 2020;55:1–14.
Sanyaolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P. Comorbidity and its Impact on Patients with COVID-19. SN Compr Clin Med 2020;
Karyono D, Wicaksana A. Current Prevalence, Characteristics, and Comorbidities of Patients with COVID-19 in Indonesia. J Community Empower Heal [Internet] 2020;3(2):77. Available from: https://jurnal.ugm.ac.id/jcoemph/article/view/57325
Biswas M, Rahaman S, Biswas T, Haque Z, Ibrahim B. Association of Sex, Age, and Comorbidities with Mortality in COVID-19
Patients: A Systematic Review and Meta- Analysis. Intervirology [Internet] 2021;64(1):36–47. Available from: https://www.karger.com/Article/FullText/512
Zhang J, Dong X, Cao Y, Yuan Y. Clinical Characteristics of 140 Patients Infected with SARS-CoV-2 in Wuhan, China. Allergy [Internet] 2020;75(7):1730–1741. Available from: https://onlinelibrary.wiley.com/
Chatterjee N, Jensen P, Harris A, Nguyen D, Huang H, Cheng R. Admission Respiratory Status Predicts Mortality in COVID-19. Influ Other Respi Viruses [Internet] 2021;15(5):569–572. Available from: https://onlinelibrary.wiley.com/
Tharakan S, Nomoto K, Miyashita S, Ishikawa K. Body Temperature Correlates with Mortality in COVID-19 Patients. Crit Care [Internet] 2020;24(1):298. Available from: https://forum.biomedcentral.com/articles/
Mejía F, Medina C, Cornejo E, Morello E, Vásquez S, Alave J. Oxygen Saturation as a Predictor of Mortality in Hospitalized Adult Patients with COVID-19 in a Public Hospital in Lima, Peru. PLoS One [Internet] 2020;15(12):1–11. Available from: https://dx.plos.org/
Chidambaram V, Tun N, Haque W, Majella M, Sivakumar R, Kumar A. Factors Associated with Disease Severity and Mortality Among Patients with COVID-19: A Systematic Review and Meta-analysis. PLoS One [Internet] 2020;15(11):1–10. Available from: https://dx.plos.org/
Wang W, Shen M, Tao Y, Fairley C, Zhong Q, Li Z. Elevated Glucose Level Leads to Rapid COVID-19 Progression and High Fatality. BMC Pulm Med [Internet] 2021;21(1):64. Available from: https://bmcpulmmed.biomedcentral.com/arti cles/
Lim S, Bae J, Kwon H-S, Nauck M. COVID-19 and Diabetes Mellitus: from Pathophysiology to Clinical Management. Nat Rev Endocrinol 2020;1–20.
Yusnanda. Data Diabetes Melitus di Kota Banda Aceh: Dinas Kesehatan Kota Banda Aceh [Internet]. Dinas Kesehat. Banda Aceh2018 [cited 2021 Oct 20];1–10. Available from: http://repository.unmuha.ac.id/xmlui/bitstream/handle/123456789/142/7. BAB I.pdf?sequence=9&isAllowed=y
Nishiga M, Wang D, Han Y, Lewis D, Wu J. COVID-19 and Cardiovascular Disease: from Basic Mechanisms to Clinical Perspectives. Nat Rev Cardiol 2020;1–16.
DOI: https://doi.org/10.36497/jri.v42i4.288
Refbacks
- There are currently no refbacks.
Copyright (c) 2022 Heliyana Isma, Yunita Arliny, Dewi Behtri Yanifitri, Budiyanti, Teuku Zulfikar
INDEXING & PARTNER
Jurnal Respirologi Indonesia pISSN: 0853-7704 - eISSN: 2620-3162 Address: Jalan Cipinang Bunder No. 19, Cipinang, Pulogadung, Jakarta Timur, DKI Jakarta 13240, Indonesia Phone: +62-21-2247-4845 Email: editor@jurnalrespirologi.org | An official publication by the Indonesian Society of Respirology (ISR) |
Creative Commons Attribution-NonCommercial 4.0 International License Statcounter |