The Depiction of Lung Function and Fractional-Exhaled Nitric Oxide (FeNO) among Asthmatic Outpatients: A Preliminary Study

Authors

  • Mulkan Azhary Universitas Syiah Kuala
  • Ratnawati Ratnawati Universitas Indonesia, RSUP Persahabatan
  • Budhi Antariksa Universitas Indonesia, RSUP Persahabatan

DOI:

https://doi.org/10.36497/jri.v41i1.152

Keywords:

Asthma, Spirometer, FeNO, Lung Function

Abstract

Background: Asthma is a heterogeneous disease manifested by airway inflammation and wheezing, dyspnea, breathlessness and cough which are varied in intensity and time accompanied with variably restricted expiratory airflow. Asthma patients experienced decreased lung function that occured during asthma attack accompanied by increased levels of fractional-exhaled nitric oxide (FeNO) caused by the pathophysiological process of asthma and the resulting ventilation problems. The study aimed to reveal the depiction of lung function using spirometry dan FeNO level among asthmatic outpatients. Methods: This was a cross sectional study involving 13 uncontrolled-moderate persistent asthmatic outpatients at Asthma Clinic of Persahabatan General Hospital during October 2019 – March2020. The involved respondents had to undergo the spirometry test and the measurement of FeNO level. Results: The uncontrolled-moderate persistent asthmatic patients were dominated by female with mean age of 48.38+12.494 years old. The mean predicted FEV1 was 70.38+20.230% of whom 61.54% patients showed moderate obstruction. The mean FEV1/FVC ratio was 72.85+12.681% of whom 53.85% patients showed obstruction inFEV1/FVC ratio. The mean FeNO level was 29.62+9.152 ppb of whom 76.92% patients had FeNO level ranging 25-50 ppb. Conclusion: The moderate persistent asthmatic patients showed a decreased lung function with reduction of FEV1, obstructive FEV1/FVC ratio as well as increasing FeNO level.

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Author Biographies

  • Mulkan Azhary, Universitas Syiah Kuala
    Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran
  • Ratnawati Ratnawati, Universitas Indonesia, RSUP Persahabatan
    Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran
  • Budhi Antariksa, Universitas Indonesia, RSUP Persahabatan
    Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran

References

GINA. Global strategy for asthma management and prevention (2018 update) [Internet]. 2018 [cited 2018 Mar 17]. Available from: http://ginasthma.org/2018-gina-report-global-strategy-for-asthma-management-and-prevention/

Gauthier M, Ray A, Wenzel SE. Evolving Concepts of Asthma. Am J Respir Crit Care Med. 2015;192(6):660.

Gemicioglu B, Musellim B, Dogan I, Guven K. Fractional exhaled nitric oxide (FeNo) in different asthma phenotypes. Allergy Rhinol. 2014 Jan;5(3):157–61.

Reddel HK, Bateman ED, Becker A, Boulet L-P, Cruz AA, Drazen JM, et al. A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J. 2015;46(3):622.

Zaini J. Asthma control test : cara simpel dan efektif untuk menilai derajat dan respons terapi asma. J Respir Indo. 2011;31(2):1–2.

Shaker A. Study of obstructive sleep apnea (OSA) in asthmatics. Egypt J Chest Dis Tuberc. 2017 Apr 1;66(2):293–8.

Huang Y-C, Yang M-C. Associations between occupational inhalation risks and FeNO levels in airway obstruction patients: results from the National Health and Nutrition Examination Survey, 2007–2012. Int J COPD. 2017;12:3085.

Shen TC, Lin C-L, Wei CC, Chen CH, Tu CY, Hsia TC, et al. Risk of obstructive sleep apnea in adult patients with asthma: a population-based cohort study in Taiwan. PLoS One. 2015;10(6):1–11.

Karrasch S, Linde K, Rücker G. Accuracy of FE NO for diagnosing asthma: a systematic review. Thorax. 2017;72:109–16.

Published

2021-01-31

Issue

Section

Original Article

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