Albumin Supplementation on Albumin Serum Level, CD8+ Lymphocyte Cell Count and Interferon Gamma Level in Rifampicin-Resistant TB Patients at Saiful Anwar Hospital Jawa Timur
DOI:
https://doi.org/10.36497/mks4dp40Keywords:
Albumin, Albumin Levels, CD8 Lymphocytes, IFN-ɣ, TB RRAbstract
Background: Drug-resistant tuberculosis (TB-RO) is still a health threat in the world, plus there are cases that do not respond to the administration of rifampicin. Diagnosis of Rifampicin Resistant TB (TB RR) requires a multidisciplinary approach, markers such as Interferon gamma (IFN-ɣ) are useful for the diagnosis, follow-up, therapy, and prognosis of TB RR. Hypoalbuminemia accompanies TB patients, as seen from weight loss and albumin in the serum of TB patients. TB infection stimulates cytokines that impact on decreasing the regulation and synthesis of albumin, as well the prognosis and success of TB therapy, especially RR TB. This study aims to determine the role of albumin supplementation on increase of albumin serum level, increase of CD8+ lymphocyte cell count, and increase of IFN-ɣ level in RR TB patients.
Methods: This True Experimental Pre and Post-Test Control Group Design research was conducted at Saiful Anwar Hospital. The subjects were 30 people, consisting of 10 people in the Healthy Group (Control Group), 10 TB RR patients were given Albumin (egg white extract) for 30 days (RR TB albumin), and 10 TB patients were not given Albumin (RR TB Non albumin). Samples were taken from peripheral blood, before and after the administration of ATD and Albumin, then analysed with Flowcytometry technique. Data result analysed with SPSS and PLS.
Results: There were differences in albumin and IFN-ɣ levels before supplementation, between the control group and RR TB patients. There was no difference in the number of CD8+ lymphocytes (p=0.402) and IFN-ɣ levels (p=0.390) in RR TB patients who were given albumin or not, but there were differences in albumin levels (p=0.003) and weight gain (p=0.014).
Conclusion: Albumin administration has the effect of increasing albumin levels and weight gain, but has no effect on CD8+ lymphocyte cell counts and IFN-ɣ levels in RR TB patients.Downloads
References
WHO. Tuberculosis. 2023. Available at: https://www.who.int/en/news-room/fact-sheets/detail/tuberculosis.
TB Team, Ministry of Health of the Republic of Indonesia, 2023
Jilani, T., Avula, A. and Zafar Gondal, A. Active Tuberculosis, StatPearls [Internet]. 2023.
Tseng, S.-H. et al. Albumin and interferon-β fusion protein serves as an effective vaccine adjuvant to enhance antigen-specific CD8+ T cell-mediated antitumor immunity. Journal for ImmunoTherapy of Cancer. 2022;10(4):e004342.
Pratama, H. Pengaruh Ekstrak Albumin Ikan Gabus (Chana striata) terhadap Kadar IFN Pasien Tuberkulosis Paru dengan Pengobatan Fase Intensif. e-Jurnal Pustaka Kesehatan. 2016;4(2):222-228.
Balaka, K.I., Apriyanto and Ishar, I. Hubungan Indeks Massa Tubuh dengan Kadar Albumin pada Penderita Tuberkulosis Paru yang Menjalani Terapi Obat Anti Tuberkulosis (OAT) di Rumah Sakit Benyamin Guluh Kolaka. Jurnal Analis Kesehatan Kendari. 2023;5(2):65-70.
Hu, S., Guo, J., Chen, Z., Gong, F. and Yu, Q. Nutritional Indices Predict All Cause Mortality in Patients with Multi-/Rifampicin-Drug Resistant Tuberculosis. Infection and Drug Resistance. 2024;17:3253–3263.
Liu, R., Shu, W., Song, Y., Liu, Y., Ma, L. and Gao, M. Use of Serum Albumin Level as a Predictive Marker of Clinical Outcomes for Active Tuberculosis. Annals of Clinical & Laboratory Science. 2020;50(5):681–686.
Ukibe, N.R., Ndiuwem, C.K., Ogbu, I.I., Ukibe, S.N., Ehiaghe, F.A. and Ikimi, C.G. Prognostic value of some serum protein fractions as Early Index of Clinical Recovery in Pulmonary Tuberculosis subjects. Indian Journal of Tuberculosis. 2020;67(2): 167–171.
Janmeja, A.K., Aggarwal, D. and Dhillon, R. Factors predicting treatment success in multi-drug resistant tuberculosis patients treated under programmatic conditions. Indian Journal of Tuberculosis. 2018;65(2):135–139.
Svensson, E.M., Dosne, A.G. and Karlsson, M.O. Population Pharmacokinetics of Bedaquiline and Metabolite M2 in Patients with Drug-Resistant Tuberculosis: The Effect of Time-Varying Weight and Albumin. CPT: Pharmacometrics and Systems Pharmacology. 2016;5(12):682–691.
Sari, D.K., Mega, J.Y. and Harahap, J. Nutrition status related to clinical improvement in AFB-positive pulmonary tuberculosis patients in primary health centres in Medan, Indonesia. Open Access Macedonian Journal of Medical Sciences. 2019;7(10):1621–1627.
Gopinath, P. and Ganesan, H. Prevalence of hypoalbuminemia among tuberculosis patients receiving anti tuberculosis therapy: A cross sectional study. International Journal of Advanced Biochemistry Research. 2019;3(2): 9–13.
Berktas, M, Guducuoglu H, Bozkurt H, Onbasi KT, Kurtoglu MG, Andic S. Change in Serum Concentrations of Interleukin-2 and Interferon-γ during Treatment of Tuberculosis. Journal of International Medical Research. 2004;32(3):324–330.
Published
Issue
Section
License
Copyright (c) 2025 Adrian Yusdianto, Iin Noor Chozin, Teguh Rahayu Sartono, Rezki Tantular, Syahrul Chilmi, Nanik Setijowati
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
- The authors own the copyright of published articles. Nevertheless, Jurnal Respirologi Indonesia has the first-to-publish license for the publication material.
- Jurnal Respirologi Indonesia has the right to archive, change the format and republish published articles by presenting the authors’ names.
- Articles are published electronically for open access and online for educational, research, and archiving purposes. Jurnal Respirologi Indonesia is not responsible for any copyright issues that might emerge from using any article except for the previous three purposes.
