The Comparison Between Risk Factors of Invasive Candidiasis and 1,3-β-D-Glucan in Septic Pneumonia

Authors

  • Dwi Rosa Eka Agustina Brawijaya University https://orcid.org/0000-0002-5418-0428
  • Ungky Agus Setyawan Universitas Brawijaya, RSUD Dr. Saiful Anwar Malang
  • Teguh Rahayu Sartono Universitas Brawijaya, RSUD Dr. Saiful Anwar Malang

DOI:

https://doi.org/10.36497/jri.v40i4.132

Keywords:

1, 3-β-D-Glucan, sepsis, pneumonia, invasive candidiasis, risk factors

Abstract

Background: Invasive candidiasis (IC) occurs in immunocompromised and immunocompetent patients. It represents the 4th bloodstream infection in the ICU. Selection of patient characteristics based on risk factors in the 1,3-β-D-Glucan (BDG) examination provided a learning value in IC screening. The aim of this study was to assess the comparison of risk factors for IC and BDG levels using a cut off value of ≥80 pg/dl. Method: this cross-sectional study was conducted in 40 patients with septic pneumonia in ICU who had the risk factors of IC (multifocal colonization, broad-spectrum antibiotics, long term use of corticosteroids, and lymphocyte status) at Saiful Anwar Malang General Hospital. Results: There were 40 patients with risk factors of IC had positive BDG, but only 1 patient (2,5%) had candidemia and 14 patients (35%) had Candida sp from sputum culture. Comparison of BDG levels between group which used broad-spectrum antibiotics and those that did not wassignificant (P=0.020). Rank Spearman linear regression of the lymphocyte <1.200 cells/mm3 on BDG levels had a positive correlation (r=2.7%, P=0.880) while linear regression of the lymphocyte <1.200 cells/mm3 had a negative correlation (r=-32.1%, P=0.428). Conclusion: Septic pneumonia patients with Candida risk factors in the ICU might have superinfection with IC. The use of broad-spectrum antibiotics affected BDG levels more significant than other risk factors.

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Author Biographies

  • Dwi Rosa Eka Agustina, Brawijaya University
    Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran
  • Ungky Agus Setyawan, Universitas Brawijaya, RSUD Dr. Saiful Anwar Malang
    Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran
  • Teguh Rahayu Sartono, Universitas Brawijaya, RSUD Dr. Saiful Anwar Malang
    Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran

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Published

2020-10-31

Issue

Vol. 40 No. 4 (2020)

Section

Original Article

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