Profile of Pulmonary Tuberculosis After COVID-19 at Toba District, North Sumatra Province
DOI:
https://doi.org/10.36497/jri.v44i4.716Keywords:
after COVID-19, COVID-19, PTB, pulmonary tuberculosisAbstract
Background: Worldwide cases of pulmonary tuberculosis (PTB) have significantly increased since the COVID-19 pandemic. Indonesia accounted for 6,811,818 of the 767,518,723 cases reported by the World Health Organization. While the Indonesian Ministry of Health reported 824,000 cases, the Global Tuberculosis Report in 2022 reported 10.6 million cases. The pandemic has hampered the goal of eliminating PTB globally, with cases diagnosed after COVID-19 having a 7.15-fold increased risk of contracting the illness.
Methods: This cross-sectional study was conducted using total sampling to identify the profile of patients with PTB after having COVID-19 based on age, gender, classification, and type of PTB, as well as the duration of occurrence of PTB after COVID-19. The data collected were from COVID-19 patients from 2020 to 2022, then compared with PTB data. All data were compared to ensure that COVID-19 and PTB patient data were the same.
Results: Of the 2544 patients recorded, 29 (1.1%) were infected with PTB after COVID-19 infection. The mean age of patients was 34±18.9 and was dominated by men (68.9%). Most of the cases were drug-sensitive TB (96.6%) and clinically diagnosed TB (55.2%). Age had a statistically significant association with the occurrence of TB cases after COVID-19 infection (P<0.0001). The mean time from the initial diagnosis of COVID-19 to the diagnosis of confirmed TB was approximately 203±34.3 days (6.7 months).
Conclusion: After COVID-19, patients have the potential to be infected with TB. Screening former COVID-19 patients can be one solution to finding early cases of PTB.
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References
Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Sumatera Utara. Tuberkulosis paru. In: Soeroso L, Syafiuddin T, Amir Z, Pandia P, Widirahardjo, Siagian P, et al., editors. Buku ajar respirasi. Medan: Fakultas Kedokteran Universitas Sumatera Utara; 2017. p. 65.
World Health Organization. Global tuberculosis report 2022 [Internet]. 2022 [cited 2023 Oct 15]. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022
World Health Organization. Global tuberculosis report 2021 [Internet]. 2021 [cited 2023 Oct 15]. Available from: https://www.who.int/publications/digital/global-tuberculosis-report-2021
Yayasan KNCV Indonesia. Laporan kasus tuberkulosis (TBC) Global dan Indonesia 2022 [Internet]. 2022 [cited 2023 Oct 15]. Available from: https://yki4tbc.org/laporan-kasus-tbc-global-dan-indonesia-2022/
Perhimpunan Dokter Paru Indonesia (PDPI), Perhimpunan Dokter Spesialis Kardiovaskular Indonesia, Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia, Perhimpunan Dokter Anestesiologi dan Terapi Intensif Indonesia, Ikatan Dokter Anak Indonesia. Pedoman tatalaksana COVID-19. 4th ed. Pedoman tatalaksana COVID-19 edisi 4. Indonesia; 2022.
Khayat M, Fan H, Vali Y. COVID-19 promoting the development of active tuberculosis in a patient with latent tuberculosis infection: A case report. Respir Med Case Rep. 2021;32.
Pozdnyakov A, Jin A, Bader M. Reactivation of pulmonary tuberculosis in a patient with COVID-19: Case report and review of literature. Infectious Diseases in Clinical Practice. 2021;29(6):e468–70.
He G, Wu J, Shi J, Dai J, Gamber M, Jiang X, et al. COVID-19 in tuberculosis patients: A report of three cases. J Med Virol. 2020;92(10):1802–6.
Sarinoglu RC, Sili U, Eryuksel E, Yildizeli SO, Cimsit C, Yagci AK. Tuberculosis and COVID-19: An overlapping situation during pandemic. J Infect Dev Ctries. 2020;14(7):721–5.
Kementerian Kesehatan Republik Indonesia. Strategi Nasional penanggulangan tuberkulosis di Indonesia 2020-2024. Pertemuan Konsolidasi Nasional Penyusunan STRANAS TB. Indonesia; 2020.
Khan MS, Rego S, Rajal JB, Bond V, Fatima RK, Isani AK, et al. Mitigating the impact of COVID-19 on tuberculosis and HIV services: A cross-sectional survey of 669 health professionals in 64 low and middle-income countries. PLoS One. 2021;16(2):e0244936.
Visca D, Ong CWM, Tiberi S, Centis R, D’Ambrosio L, Chen B, et al. Tuberculosis and COVID-19 interaction: A review of biological, clinical and public health effects. Pulmonology. 2021;27(2):151–65.
Parker A, Boloko L, Moolla MS, Ebrahim N, Ayele BT, Broadhurst AGB, et al. Clinical features and outcomes of COVID-19 admissions in a population with a high prevalence of HIV and tuberculosis: A multicentre cohort study. BMC Infect Dis. 2022;22(1):559.
Kumwichar P, Chongsuvivatwong V. COVID-19 pneumonia and the subsequent risk of getting active pulmonary tuberculosis: A population-based dynamic cohort study using national insurance claims databases. EClinicalMedicine. 2023;56:101825.
Dinas Kesehatan Provinsi Sumatera Utara. Laporan tahunan TB paru tahun 2022. 2022.
Dinas Kesehatan Kabupaten Toba. Laporan Tahunan TB Paru tahun 2022. 2022.
Burhan E, Isbaniah F, Aditama TY. Tuberkulosis dan COVID-19. Vol. 1, Fakultas Kedokteran Universitas Indonesia. Jakarta: FKUI; 2021. 14–20 p.
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. The Lancet. 2020;395(10224):565–74.
Wang Z, Yang B, Li Q, Wen L, Zhang R. Clinical features of 69 cases with coronavirus disease 2019 in Wuhan, China. Clinical Infectious Diseases. 2020;71(15):769–77.
Lucas C, Wong P, Klein J, Castro TBR, Silva J, Sundaram M, et al. Longitudinal analyses reveal immunological misfiring in severe COVID-19. Nature. 2020;584(7821):463–9.
Rydyznski Moderbacher C, Ramirez SI, Dan JM, Grifoni A, Hastie KM, Weiskopf D, et al. Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity. Cell. 2020;183(4):1012e19.
Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8(4):420–2.
Diao B, Wang C, Tan Y, Chen X, Liu Y, Ning L, et al. Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19). Front Immunol. 2020;11:827.
Jiang Y, Wei X, Guan J, Qin S, Wang Z, Lu H, et al. COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potential. Clinical Immunology. 2020;218:108516.
Huang M, Wang Y, Ye J, Da H, Fang S, Chen L. Dynamic changes of T-lymphocyte subsets and the correlations with 89 patients with coronavirus disease 2019 (COVID-19). Ann Transl Med. 2020;8(18):1145.
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