Prevalence and Determinant of Depression among Multi-Drug Resistance Tuberculosis: Study in Dr. Kariadi General Hospital

Mahalul Azam, Arulita Ika Fibriana, Fitri Indrawati, Indah Septiani


Backgrouds: Multi-drug resistance tuberculosis (MDR-TB) adds the burden of tuberculosis (TB). Depression is a common comorbidity in TB patients. Prevalence of depression among MDR-TB patients was higher, i.e. 11-70%. Prevalence of depression among TB patients in Dr. Kariadi General Hospital was 51.9%. Previous study reported the determinants related to the depression in MDR-TB patients. This study explored the prevalence of depression in MDR-TB patients and its determinants.
Methods: This study was a cross-sectional study conducted from July-August 2019. Data consisted of primary and secondary data from Dr. Kariadi General Hospital patients. Sample in this study involved 72 respondents, over 16 years old from 151 registered MDR-TB patients. Depression status was determined using Depression Anxiety Stress Scales obtained from the medical record. Subjects’ characteristics and determinants were collected from primary as well as secondary data. Descriptive data were presented in proportion. Chi-square test continued by Binary logistic regression was performed to determine the association between depression status and its determinants. A P-value <0.05 considered as statistically significant.
Results: Of 72 MDR-TB patients, 26.4% had depression status. Underweight (AOR=8.24; 95% CI=1.731-39.197), female patients (AOR=7.61; 95% CI=1.797-32.213), presence of comorbidities (AOR=7.62; 95% CI=1,748-33,204) and patient’s perception of stigma in the community (AOR=5.08; 95% CI=1.238-20.826) were significantly related to the incidence of depression in MDR-TB patients.
Conclusions: Prevalence of depression among MDR-TB patients was 26.4%. Underweight, female patient, comorbidity and the patient's perception of stigma were related to depression status. (J Respir Indo. 2020; 40(2): 88-96)


depression; multi-drug-resistance; tuberculosis; cross-sectional

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