KL-6 Serum Elevation among Supit Urang Landfill Workers: Based on Length of Work Duration and Type of Work

Authors

  • Rizki Diah Anggraeni Pulmonology and Respiratory Medicine Department, Medical Faculty of Universitas Brawijaya – Saiful Anwar General Hospital, East Java. Veteran Street, Ketawang Gede, Lowokwaru, Malang City, East Java, Indonesia, 65145. https://orcid.org/0009-0000-3472-8823
  • Tri Wahju Astuti Pulmonology and Respiratory Medicine Department, Medical Faculty of Universitas Brawijaya – Saiful Anwar General Hospital, East Java. Veteran Street, Ketawang Gede, Lowokwaru, Malang City, East Java, Indonesia, 65145. https://orcid.org/0000-0002-3748-7399
  • Fitri Indah Sari Pulmonology and Respiratory Medicine Department, Medical Faculty of Universitas Brawijaya – Saiful Anwar General Hospital, East Java. Veteran Street, Ketawang Gede, Lowokwaru, Malang City, East Java, Indonesia, 65145. https://orcid.org/0000-0003-2753-1357
  • Sastia Rakhma Pulmonology and Respiratory Medicine Department, Medical Faculty of Universitas Brawijaya – Saiful Anwar General Hospital, East Java. Veteran Street, Ketawang Gede, Lowokwaru, Malang City, East Java, Indonesia, 65145. https://orcid.org/0000-0003-1207-3082

DOI:

https://doi.org/10.36497/57wdw018

Keywords:

KL-6 serum, Duration of exposure, Work type, Waste workers, Supit Urang Landfill

Abstract

Background: KL-6 serum was a glycoprotein biomarker of lung inflammation and epithelial damage. Waste workers at Supit Urang Landfill, Malang, Indonesia has a risk from occupational inhalation exposure such as bacterial bioaerosol, VOC, CH4, CO, H2S. This study analyzed serum KL-6 serum levels as inflammation biomarker according to length of exposure duration and type of work.

Methods: The study design analytic experimental with cross-sectional approached. Total subject was 79 worker who grouped by exposure duration in 24 subjects on 1–5 years; 29 subjects on 5–10 years; 26 subjects on >10 years as. Others groups type of work consisted of 48 scavengers; 20 waste sorters as; 9 waste processors; 2 laboratories technicians. KL-6 levels were measured by ELISA. Anova and spearman-rho analysis was used for KL-6 serum level in each group.

Results: KL-6 serum level was significantly (p = 0.000) increased in workers with >10 years of exposure (1170,3 ± 621,4 U/mL) compared to the others group. Scavengers have a significantly (p = 0,002) increased of KL-6 serum level (1049,6 ± 586,6 U/mL) compared to the others groups. Moderate correlation existed between exposure duration and KL-6 serum levels with positive result (r=0.470, p=0.000).

Conclusion: The research found higher serum KL-6 levels after 10 years of exposure. Gas product exposure puts scavengers at danger of inhalation.

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Author Biographies

  • Tri Wahju Astuti, Pulmonology and Respiratory Medicine Department, Medical Faculty of Universitas Brawijaya – Saiful Anwar General Hospital, East Java. Veteran Street, Ketawang Gede, Lowokwaru, Malang City, East Java, Indonesia, 65145.

    Pulmonologist Consultant of Enviromental and occupational respiratory health at Pulmonology and Respiratory Medicine Department, Medical Faculty of Universitas Brawijaya – Saiful Anwar General Hospital, East Java.

    Veteran Street, Ketawang Gede, Lowokwaru, Malang City, East Java, Indonesia, 65145.

  • Fitri Indah Sari, Pulmonology and Respiratory Medicine Department, Medical Faculty of Universitas Brawijaya – Saiful Anwar General Hospital, East Java. Veteran Street, Ketawang Gede, Lowokwaru, Malang City, East Java, Indonesia, 65145.

    Pulmonologist Consultant of Enviromental and occupational respiratory health at Pulmonology and Respiratory Medicine Department, Medical Faculty of Universitas Brawijaya – Saiful Anwar General Hospital, East Java.

    Veteran Street, Ketawang Gede, Lowokwaru, Malang City, East Java, Indonesia, 65145.

  • Sastia Rakhma, Pulmonology and Respiratory Medicine Department, Medical Faculty of Universitas Brawijaya – Saiful Anwar General Hospital, East Java. Veteran Street, Ketawang Gede, Lowokwaru, Malang City, East Java, Indonesia, 65145.

    Pulmonologist consultant of immunology respiratory health at Pulmonology and Respiratory Medicine Department, Medical Faculty of Universitas Brawijaya – Saiful Anwar General Hospital, East Java.

    Veteran Street, Ketawang Gede, Lowokwaru, Malang City, East Java, Indonesia, 65145.

Published

2026-05-15

Issue

Vol. 46 No. 2 (2026)

Section

Original Article

License

Copyright (c) 2026 Rizki Diah Anggraeni, Tri Wahju Astuti, Fitri Indah Sari, Sastia Rakhma

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How to Cite

KL-6 Serum Elevation among Supit Urang Landfill Workers: Based on Length of Work Duration and Type of Work. (2026). Jurnal Respirologi Indonesia, 46(2). https://doi.org/10.36497/57wdw018

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