Pathophysiology of Haemoptysis in Lung Disease
Abstract
Hemoptysis is expectoration of blood with or without sputum originating from the lower airway. Hemoptysis is an alarming symptom that could
lead to massive bleeding and life-threatening condition. Based on the underlying disease, hemoptysis can occur through several different
pathological mechanisms. Mostly, hemoptysis caused by bronchiectasis, pulmonary tuberculosis, lung cancer, and pulmonary fungal
infections. The incidence rate of the causative diseases can differ depending on its geographical location. Pulmonary vascularization consists
of two circulation pathways namely the pulmonary circulation and bronchial circulation, each of which has its own role. As many as 90% of
cases of hemoptysis are caused by collapse of the bronchial arteries, due to increased pressure in its circuit. It is important to understand the
pathophysiology and pathomechanism of hemoptysis for further management on both diseases and also the clinical manifestasion.
Keywords
Full Text:
PDFReferences
Sutanto YS, Yofi I. Hemoptisis. In: Rasmin M, Jusuf A, Amin M, Nawas MA, Rai IBN, Yunus F, et al., editors. Buku Ajar Pulmonologi dan Kedokteran Respirasi Buku 2. 1st ed. Jakarta: UI Publishing; 2018. p. 299–329.
Blasi F, Tarsia P, Webb A, Angus D, Finfer S, Gattinoni L, et al. Pathophysiology and causes of haemoptysis. In: Webb A, Angus D, Finfer S, Gattinoni L, Singer M, editors. Oxford Textbook of Critical Care. 2nd ed. London: Oxford University Press; 2016. p. 1–11.
Ittrich H, Bockhorn M, Klose H, Simon M. The diagnosis and treatment of hemoptysis. Dtsch Arztebl Int. 2017;114:371–81.
Larici AR, Franchi P, Occhipinti M, Contegiacomo A, Ciello A, Calandriello L, et al. Diagnosis and management of hemoptysis. Diagn Interv Radiol. 2014;20:299–309.
Bandele TR, Ojudu OL, Afolabi DM. A study of the pathophysiology , causes and management of hemoptysis with emphasis on differential diagnosis and appropriate management. Int Sch Journals. 2015;3:215–7.
Bhatta DR, Singh T, Gokhale S. Hemoptysis : is it tuberculosis ? Int J Infect Microbiol. 2012;1:63–7.
Gagnon S, Quigley N, Dutau H, Delage A, Fortin M. Approach to hemoptysis in the modern era. Can Respir J. 2017;
Dagenais L, Materassi M, Desnous B, Vinay M-C, Doussae A, Sabeh P, et al. Superior performance in prone in infants with congenital heart disease predicts an earlier onset of walking. J Child Neurol. 2018:1–7.
Swidarmoko B. Batuk darah. In: Swidarmoko B, Susanto AD, editors. Pulmonologi intervensi dan gawat darurat napas. Jakarta: Fakultas Kedokteran Universitas Indonesia; 2010. p. 28–53.
Lordan JL, Gascoigne A, Corris PA. Assessment and management of massive haemoptysis. Thorax. 2003;58:814–9.
Walker CM, Rosado-de-christenson ML, Martínez-jiménez S, Kunin JR, Wible BC. Bronchial arteries : anatomy, function, hypertrophy, and anomalies. RadioGraphics. 2015;35:32–49.
Haworth SG, Rabinovitch M. Pulmonary circulation. In: Anderson RH, Baker EJ, Penny D, Redington AN, Rigby ML, Wernovsky G, editors. Paediatric Cardiology. Third. Philadelphia, USA: Elsevier; 2010. p. 117–41.
Bhalla AS, Goyal A, Guleria R, Gupta AK. Chest tuberculosis : Radiological review and imaging recommendations. 2015;25.
Rajamannar K V., Kilaru H, Aravelly S, Gudipati AR, Kilaru SC. Massive hemoptysis from Rasmussen’s aneurysm in active pulmonary tuberculosis; A case report of successful treatment with bronchial artery embolization. Respir Med Case Reports. 2017;22:277–9.
Kusumastrini YDS, Permatasari A. Bronchial Arteries Embolization in Tuberculosis-Related Recurrent Hemoptysis with Complete Right Lung Atelectasis: A Case Report. J Respirasi. 2022;8:33.
Tan S, Sun D, Zhang T, Li Y, Cao Y, Njire MM, et al. Risk factors for hemoptysis in pulmonary tuberculosis patients from southern china : a retrospective study. J Tubercuosis Res. 2014;2:173–80.
Tiwari VK, Bansal S, Kumar A, Kumar A. Rasmussen’s aneurysm : rare cause for massive hemoptysis in pulmonary tuberculosis patients. Int J Adv Integ Med Sci. 2016;1:36–7.
Sapra R, Sharma G, Minz AK. Rasmussen’s aneurysm : A rare and forgotten cause of hemoptysis. Indian Heart J. 2015;67:S53–6.
Peghini GE, López Y LA, Penalver PC, Morales RR. Rasmussen’s pseudoaneurysm in a patient with a history of pulmonary tuberculosis. Arch Bronconeumol. 2015;51:96–7.
Giraldo-Montoya ÁM, Rodríguez-Morales AJ, Hernández-Hurtado JD, López-Salazar Á, Lagos-Grisales GJ, Ruiz-Granada VH. Rasmussen aneurysm: A rare but not gone complication of tuberculosis. Int J Infect Dis. 2018;69:8–10.
Jin F, Li Q, Bai C, Wang H, Li S, Song Y, et al. Chinese Expert Recommendation for Diagnosis and Treatment of Massive Hemoptysis. Respiration. 2020;99:83–92.
Kimmig L, Bueno J. Dilated bronchi: how can I tell? Ann Am Thorac. 2017;14:807–9.
Razazi K, Parrot A, Khalil A, Djibre M, Gounant V, Assouad J, et al. Severe haemoptysis in patients with nonsmall cell lung carcinoma. Eur Respir J. 2015;45:756–64.
Hu P, Wang G, Cao H, Ma H, Sui P, Du J. Haemoptysis as a prognostic factor in lung adenocarcinoma after curative resection. Br J Cancer. 2013;1609–17.
Nichols L, Saunders R, Knollmann FD. Causes of death of patients with lung cancer. Arch Pathol Lab Med. 2012;136:1552–7.
Kousha M, Tadi R, Soubani AO. Pulmonary aspergillosis: A clinical review. Eur Respir Rev. 2011;20:156–74.
Shah R, Vaideeswar P, Pandit SP. Pathology of pulmonary aspergillomas. Indian J Pathol Microbiol. 2008;51:342–5.
DOI: https://doi.org/10.36497/jri.v43i1.441
Refbacks
- There are currently no refbacks.
Copyright (c) 2023 Airin Aldiani, Mohamad Fahmi Alatas
INDEXING & PARTNER
Jurnal Respirologi Indonesia pISSN: 0853-7704 - eISSN: 2620-3162 Address: Jalan Cipinang Bunder No. 19, Cipinang, Pulogadung, Jakarta Timur, DKI Jakarta 13240, Indonesia Phone: +62-21-2247-4845 Email: editor@jurnalrespirologi.org | An official publication by the Indonesian Society of Respirology (ISR) |
Creative Commons Attribution-ShareAlike 4.0 International License Statcounter |