The Effect of Curcumin On Plasma Histamine Level, PEF Variation and Length of Stay of Patients With Acute Exacerbation Asthma

Lydia Arista Sutedjo, Suradi Suradi, Ana Rima Setijadi


Introduction: Inflammation in asthma occured in airway especially in submucous layer, and involve eosinophil, neutrophil, lymphocytes T, epitheliat cel, basophil, mast cell, and lymphocytes B. Inflammatory cells produce inflammatory mediators (histamine, leucotrienes, and prostanoid), cytokines, and chemokines that can cause bronchocontriction. This study was conducted to determine and prove the effect of curcumin as adjunctive therapy in acute exacerbation asthma. Curcumin is expected to increase the quality therapy of acute exacerbation asthma. The effect of curcumin is known wiith evaluate plasma histamine level, PEF variation, and length of stay of patient with acute exacerbation asthma.
Methods: This study is a quasi experimental study with pretest and posttest design. Sampel of study is 30 patients hospitalizes acute exacerbation asthma in Moewardi hospital and Sohadi Prijonegoro Sragen hospital in August 2016 until september 2016. The subject was taken with concecutive random sampling. Independent variable is curcumin 4x550 mg and dependent variables are plasma histamin level, PEF variation, and length of stay.
Result: There is no significant difference (P=0.462) of decreasing plasma histamine level between treatment group 3,988±2,739 ng/ml and control group 3,376±1,606 ng/ml. There is no significant difference (P=0.501) of PEF variation between treatment group 28,126±7,886% and control group 30,400±10,217%. There is no significant difference (P=0.936) of length of stay between treatment group perlakuan 6,333±2,193 days and control group 6,400±2,292 days.
Conclusion: Giving curcumin in acute exacerbation asthma while hospitalized didn’t reduce inflammatory marker plasma histamin, PEF variation, and length of stay. (J Respir Indo 2018; 38(2): 100-8)


asthma, curcumin, inflammation, histamine, PEF, length of stay

Full Text:



Eder W, Ege MJ, Mutius EV. The asthma epidemic. The England Journal of Medicine. 2006;355:2226-35.

Akinbami LJ, Moorman JE, Bailey C, Zahran HS, King M, Johnson, CA. 2012. Trends in asthma prevalence, health care use, and mortality in the united states. US Department of Health and Human Services. 2012;94:1-8.

Sondik E, Madans J. National surveillance of asthma-United States: 2001-2010. Centers for Disease Control and Prevention. 2012;3:1-67.

Abidi A, Gupta S, Agarwal M, Bhalla HL, Saluja, M. 2014. Evaluation of efficacy of curcumin as add-on therapy in patient of bronchial asthma. Journal of Clinical and Diagnostic Research. 2014;8:19-24.

Barnes. Immunology of asthma and chronic obstructive pulmonary disease. Nature Rev Immunol. 2008;8:183-92.

Weinberger ES, Cockrill, B, Mandel J. Asthma. In: Weinberger ES, Cockrill, B, Mandel J, editors. Principles Pulmonary Medicine. 5th ed. Philadelphia: Elsevier; 2014.p. 74-90.

Quanjer PH, Lebowitz MD, Greg I, Miller MR, Pedersen OF. Peak expiratory flow: conclusions and recommendation of a working party of the european respiratory society. European Respiratory Journal. 1997;10:2-8.

Perhimpunan Dokter Paru Indonesia. Asma. Pedoman Diagnosis dan Penatalaksanaan di Indonesia. Jakarta: Balai Penerbit FK UI; 2006.

Karaman M, Firinci F, Cilaker S, Uysal P, Tugyan K, Yilmaz O. Anti-inflammatory effects of curcumin in a murine model of chronic asthma. Allergol Immunopathol. 2012;40:210-14.

Finn DF, Walsh JJ. Twenty-first century mast cell stabilizers. British Journal of Pharmacology. 2013;170:23-37.

Nugroho PI. Pengaruh pemberian zink pada nilai control asma, volume ekspirasi paksa detik pertama, jumlah eosinofil, dan netrofil sputum penderita asma. Tesis. RSUD Dr. Moewardi Surakarta. 2013.

Kurup VP, Barrios CS. Immunomodulatory effect of curcumin in allergy. Mol Nutr Food Res. 2008;52:1031-39.

Joe B, Vijaykumar M, Lokesh R. Biological properties of curcumin cellular and molecular mechanism of action. Critical Reviews in Food Science and Nutrition. 2004;44:97-111.

Subbarao P, Mandhane PJ, Sears M. Asthma: epidemiology, etiology and risk factors. Canadian Medical Association Journal. 2009;9:181-90.

Raharjo AF. Pengaruh vaksinasi BCG terhadap kadar IFN-γ, eosinofil sputum, dan VEP-1% pada penderita asma. Tesis. RSUD Dr. Moewardi Surakarta. 2013.

Choi I S. Gender specific asthma treatment. Allergy Asthma Immunol Res. 2011;3:74-80.

Estika W, Iskandar H. Hubungan kadar adiponektin dengan derajat keparahan asma dan obstruksi saluran napas. Indonesian Journal Of Chest Critical And Emergency Medicine. 2014;1:17-20.

Ford ES, Mannino DM, Redd SC, Mokdad AH, Mott JA. Body mass index and asthma incidence among USA adults. European Respiratory Journal. 2004;24:740–4.

Sood A, Ford ES, Camago CA. Association between leptin and asthma in adults. Thorax. 2006;61:300-5.

Eagan TM, Gulsvik A, Eide GE, Bake PS. The effect of educational level on the incidence of asthma and respiratory symptoms. Respir Med. 2004;98:730-6.

Hart, P. Regulation of the inflammatory response in asthma by mast cell products. Immunology and cell biology. 2001;79:149-53.

Kim DH, Phillips JF, Lockey FL. Oral curcumin supplementation in patient with atopic asthma. Allergy Rhinol. 2011;2:1-3.

Li X, Lu Y, Son JK, Lee SH, Chang HW. Curcumin inhibits the activation of immunoglobulin e-mediated mast cells and passive systemic anaphylaxis in mice by reducing serum eicosanoid and histamine levels. Biomol Ther. 2014;22:27-34.

Micucci M, Aldini R, Cevenini M, Colliva C, Spinozzi S, Roda G. Curcuma longa l. as a therapeutic agent in intestinal motility disorders: safety profile in mouse. Plos One. 2013;8:1-13.



  • There are currently no refbacks.

Copyright (c) 2018 Jurnal Respirologi Indonesia


SINTA Garuda Indonesian Scientific Journal Database (ISJD) Indonesia One Search (IOS) Crossref

ROAD-ISSN Dimensions Google Scholar 


Jurnal Respirologi Indonesia
pISSN: 0853-7704 - eISSN: 2620-3162
Address: Jalan Cipinang Bunder No. 19, Cipinang, Pulogadung, Jakarta Timur, DKI Jakarta 13240, Indonesia
Phone: +62-21-2247-4845

An official publication by
the Indonesian Society of Respirology (ISR)

Creative Commons License
Creative Commons Attribution-NonCommercial 4.0 International License